Metabolic
5-Amino-1MQ
Body recomp via NNMT inhibition
Mechanism
Inhibits NNMT, shifts methyl/NAD metabolism
Frequency
Daily
Clinical benefits
Synergistic compounds
46 peptide reference cards — mechanism of action, typical dosing, cycle length, and synergistic compounds. Understand what each peptide does and how it fits into a protocol.
Metabolic
Body recomp via NNMT inhibition
Mechanism
Inhibits NNMT, shifts methyl/NAD metabolism
Frequency
Daily
Clinical benefits
Synergistic compounds
Cognitive & Nootropic
High-potency Semax analog
Mechanism
Adamantyl-modified neurotrophic peptide; BDNF/TrkB and dopamine optimization
Frequency
Daily
Clinical benefits
Synergistic compounds
Metabolic
Fat mobilization support
Mechanism
Lipolysis signaling via GH C-terminal fragment
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Neuropathic pain & nerve healing
Mechanism
Innate repair receptor agonist, tissue-protective signaling
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Body protection compound
Mechanism
Angiogenesis, NO signaling, fibroblast migration
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Cartilage & joint support
Mechanism
Gene-expression normalization in chondrocytes
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Extended GHRH analog for pulsatile GH
Mechanism
GHRH-R agonist with albumin-binding DAC tail; 5-8 day half-life
Frequency
Weekly
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Short-acting GHRH analog (Mod GRF 1-29)
Mechanism
GHRH-R agonist; ~30 min half-life, daily/multi-daily cadence
Frequency
Daily
Clinical benefits
Synergistic compounds
Cognitive & Nootropic
Sleep onset & circadian support
Mechanism
Modulates sleep-arousal networks via hypothalamic signaling
Frequency
Daily
Clinical benefits
Synergistic compounds
Anti-Aging
Circadian & longevity support
Mechanism
Telomere/clock-gene regulation, melatonin modulation
Frequency
Daily
Clinical benefits
Synergistic compounds
Anti-Aging
Senolytic research peptide (preclinical)
Mechanism
D-retro-inverso TAT-fused peptide; disrupts FOXO4-p53 to clear senescent cells
Frequency
Every 3 days
Clinical benefits
Synergistic compounds
Cosmetic
Collagen synthesis & skin remodeling
Mechanism
Up-regulates collagen/elastin, down-modulates MMPs
Frequency
3×/week
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Legacy ghrelin-receptor GH pulse
Mechanism
GHS-R1a agonist; GH pulse with cortisol/prolactin spillover
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Older appetite-heavy GH secretagogue
Mechanism
GHS-R1a agonist; heavier hunger, cortisol, and prolactin than newer agents
Frequency
Daily
Clinical benefits
Synergistic compounds
Immune Modulators
Master antioxidant & detox substrate
Mechanism
Tripeptide redox buffer; NADPH-dependent recycling; phase 2 detox conjugation
Frequency
3×/week
Clinical benefits
Synergistic compounds
HPTA Axis
Testicular maintenance & fertility
Mechanism
Mimics LH; stimulates Leydig/theca cells
Frequency
Every other day
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Master anabolic hormone
Mechanism
191-aa pituitary hormone; JAK2/STAT5; IGF-1 axis
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Myogenic driver for tissue repair
Mechanism
Modified IGF-1 with extended half-life; PI3K-Akt-mTOR; satellite-cell proliferation
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Clean GH secretagogue
Mechanism
Selective GHS-R agonist; GH release without prolactin/cortisol
Frequency
Daily
Clinical benefits
Synergistic compounds
HPTA Axis
HPG-axis support
Mechanism
Stimulates GnRH neurons; pulsatile LH/FSH release
Frequency
3×/week
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Anti-inflammatory peptide
Mechanism
α-MSH fragment, NF-κB down-regulation, mast-cell stabilization
Frequency
Daily
Clinical benefits
Synergistic compounds
Metabolic
Fat oxidation & endurance
Mechanism
Carnitine shuttle for fatty-acid transport into mitochondria
Frequency
Daily
Clinical benefits
Synergistic compounds
Cosmetic
MC1R-selective photoprotector
Mechanism
Selective MC1R agonist; eumelanin synthesis; DNA repair enhancement
Frequency
2×/week
Clinical benefits
Synergistic compounds
Cosmetic
Non-selective melanocortin agonist (unapproved)
Mechanism
Cyclic peptide; activates MC1R/MC3R/MC4R/MC5R — tanning, sexual function, appetite suppression
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Oral ghrelin-receptor GH secretagogue
Mechanism
Small-molecule GHS-R1a agonist; raises GH and IGF-1 orally
Frequency
Daily
Clinical benefits
Synergistic compounds
Metabolic
Mitochondrial peptide for metabolic flexibility
Mechanism
AMPK activation, metabolic flexibility enhancement
Frequency
2-3x-weekly
Clinical benefits
Synergistic compounds
Anti-Aging
Foundational energy substrate
Mechanism
Universal cofactor for ATP and sirtuin activity
Frequency
2-3x-weekly
Clinical benefits
Synergistic compounds
HPTA Axis
Bonding & autonomic state signal
Mechanism
OXTR agonism; threat processing, social salience, autonomic state
Frequency
As needed
Clinical benefits
Synergistic compounds
Cognitive & Nootropic
Neuroplasticity enhancer
Mechanism
BDNF upregulation, synaptic plasticity enhancement
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Anti-inflammatory fatty-acid amide (oral)
Mechanism
PPAR-α activation, mast-cell ALIA signaling, TRPV1 modulation
Frequency
BID
Clinical benefits
Synergistic compounds
Anti-Aging
CNS trophic support
Mechanism
Oligopeptide regulatory effects on brain tissue
Frequency
Daily
Clinical benefits
Synergistic compounds
HPTA Axis
Sexual desire signal (FDA-approved HSDD)
Mechanism
Non-selective melanocortin agonist; central arousal circuitry
Frequency
As needed
Clinical benefits
Synergistic compounds
GLP-1 Agonists
Triple agonist for aggressive fat loss
Mechanism
GLP-1 (satiety), GIP (insulinotropic), glucagon (lipolysis) agonist
Frequency
Weekly
Clinical benefits
Synergistic compounds
Cognitive & Nootropic
Anxiolytic & stress resilience
Mechanism
Tuftsin analog, GABAergic modulation, anti-inflammatory
Frequency
Daily
Clinical benefits
Synergistic compounds
GLP-1 Agonists
GLP-1 for weight loss & CV protection
Mechanism
GLP-1R agonism with long half-life
Frequency
Weekly
Clinical benefits
Synergistic compounds
Cognitive & Nootropic
Cognitive drive & focus
Mechanism
ACTH analog, BDNF up-regulation, dopaminergic modulation
Frequency
Daily
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Pulsatile GH release
Mechanism
Pulsatile GH release from pituitary, modest IGF-1 rise
Frequency
Daily
Clinical benefits
Synergistic compounds
Anti-Aging
Mitochondrial function optimizer
Mechanism
Binds cardiolipin, stabilizes cristae, improves electron transport
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Soft-tissue healing accelerator
Mechanism
Actin-sequestering, cell migration, angiogenesis
Frequency
2×/week
Clinical benefits
Synergistic compounds
Growth Hormone Axis
Visceral fat reduction via GH
Mechanism
Stimulates pituitary GH release, IGF-1 elevation, lipolysis
Frequency
Daily
Clinical benefits
Synergistic compounds
Immune Modulators
Russian thymic extract complex
Mechanism
Short thymic peptides (KE, EW, EDP fractions); transcription and hematopoietic signaling
Frequency
Daily
Clinical benefits
Synergistic compounds
Healing & Tissue Repair
Full-length TB-4 (verify vs TB-500 fragment)
Mechanism
G-actin sequestration, Ac-SDKP release, anti-fibrotic signaling
Frequency
2×/week
Clinical benefits
Synergistic compounds
Immune Modulators
Immune modulation & post-viral support
Mechanism
Enhances T-cell function, upregulates MHC, rebalances Th1/Th2
Frequency
Daily
Clinical benefits
Synergistic compounds
Immune Modulators
Zinc-dependent thymic immune signal
Mechanism
T-cell differentiation, NK cell activity, neuroendocrine stress-immune crosstalk
Frequency
Daily
Clinical benefits
Synergistic compounds
GLP-1 Agonists
Dual agonist for weight & T2D control
Mechanism
GLP-1 satiety/gastric delay + GIP insulinotropic effects
Frequency
Weekly
Clinical benefits
Synergistic compounds
Immune Modulators
MCAS & dysautonomia support
Mechanism
VPAC receptor activation; anti-inflammatory; mast-cell modulation
Frequency
Daily
Clinical benefits
Synergistic compounds