GLP-1s
Semaglutide, tirzepatide, and retatrutide are three different receptor strategies — not three doses of the same drug. Each one answers the same question about hunger, fat, and lean mass in a different way.
Three compounds, three receptor strategies. Semaglutide activates GLP-1 alone — SELECT showed a 20% cardiovascular event reduction in obesity with established heart disease. Tirzepatide adds GIP and delivered 47% more weight loss than semaglutide in the head-to-head SURMOUNT-5 trial. Retatrutide adds glucagon on top, pushing the weight-loss ceiling higher and mobilizing liver fat directly, though it remains investigational. Pick by the outcome you need, not the headline number.
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Compound Guides
SemaglutideOzempicWegovy
Semaglutide dosing ranges from 0.25mg to 2.4mg a week. How much weight loss to expect by dose, side effects during titration, and if Ozempic or Wegovy is right for you.
TirzepatideMounjaroZepbound
Tirzepatide dosing ranges from 2.5mg to 15mg. Explore trial data for weight loss, side effects vs. semaglutide, and if Mounjaro or Zepbound makes sense for you.
Read guideRetatrutideTriple-Agonist GLP-1
Retatrutide is the next evolution of Ozempic and Mounjaro — hitting GLP-1, GIP, and glucagon receptors simultaneously — fundamentally altering metabolic health.
Read guideDeep Dives
GLP-1 FatigueWhy It Happens and What Helps
GLP-1 fatigue explained: why semaglutide, tirzepatide, and retatrutide cause tiredness, which compound causes more, and evidence-based fixes from protein to mitochondrial support.
GLP-1s and Cholesterol
GLP-1 drugs also improve lipid panels—lowering triglycerides, shifting LDL, and reducing liver fat. Trial data for semaglutide, tirzepatide, and retatrutide.
Read guideOral GLP-1 OptionsWegovy PillOrforglipron
There's now a pill version of semaglutide, and orforglipron is coming. How they compare on weight loss, side effects, and cost — and if its right for you.
Read guideSupport Stacks for GLP-1sPreserving Lean Mass
Semaglutide and Tirzepatide can cause up to 40% muscle loss. Learn why, what 'Ozempic face' actually is, and the evidence-based protocol to prevent it.
Read guideProtocols
NAD+ for RetatrutideCritical Support Layer for GLP-1s
Retatrutide creates a powerful caloric deficit, but needs NAD+ to oxidize fat and prevent energy crashes. Full protocol — dosing, timing, and what to expect.
NAD+ and MOTS-c for EnergyThe Two-Compound Mito Stack
The NAD+ and MOTS-c stack restores the cellular adaptation loop that metabolic stress and age erodes, increasing energy by burning fat for fuel. Full protocol with dosing breakdowns and a 12-week timeline.
Read guideRetatrutide: Advanced StackDual-Axis Protocol to Protect Lean Mass
A novel protocol for Retatrutide to preserve lean mass and shift your metabolism to prefer fat for energy using MOTS-c, Tesamorelin, L-Carnitine, and NAD+.
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