Schedule A
Moderate stability2 mg every 7 days
Week 6 · Day 0 · Injection3.59 mg eq.
Peak
3.61 mg eq.
Lower peaks track fewer side effects
Δ Delta
2.24×
- Trough
- 1.61 mg eq.
- Average
- 2.47 mg eq.
- Spread
- 2.00 mg eq.
- 95% steady state
- Reached by shot 4
GLP-1 Plotter
Compare how dose and interval change the weekly level and 12-week accumulation curve.
Schedule A
Modeled level in mg eq.
How to Read the Half-Life View
Retatrutide uses a 6-day half-life in this view. Each injection appears at its full dose at the moment it is given, then the amount falls by half every 6 days. A weekly dose still has about 45% remaining when the next dose is given, so the doses overlap.1
The result is shown in mg eq. It is a dose-and-time estimate, not a lab measurement. The view makes schedule changes easy to compare, but it does not model the hours a subcutaneous injection takes to absorb.
Injection table
Schedule A
2 mg every 7 days
Δ Delta2.24×
| Shot | 01 | 02 | 03 | 04 | 05 | 06 | 07 | 08 | 09 | 10 | 11 | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Injection day | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | Day 49 | Day 56 | Day 63 | Day 70 | Day 77 |
| Peakmg eq. | 2.00 | 2.89 | 3.29 | 3.46 | 3.54 | 3.58 | 3.59 | 3.60 | 3.60 | 3.61 | 3.61 | 3.61 |
| Troughmg eq. | 0.89 | 1.29 | 1.46 | 1.54 | 1.58 | 1.59 | 1.60 | 1.60 | 1.61 | 1.61 | 1.61 | 1.61 |
| Steady statepeak reached | 55% | 80% | 91% | 96% | 98% | 99% | 100% | 100% | 100% | 100% | 100% | 100% |
Schedule A
2 mg every 7 days
Δ Delta2.24×
| Shot | Injection day | Peakmg eq. | Troughmg eq. | Steady statepeak reached |
|---|---|---|---|---|
| 01 | Day 0 | 2.00 | 0.89 | 55% |
| 02 | Day 7 | 2.89 | 1.29 | 80% |
| 03 | Day 14 | 3.29 | 1.46 | 91% |
| 04 | Day 21 | 3.46 | 1.54 | 96% |
| 05 | Day 28 | 3.54 | 1.58 | 98% |
| 06 | Day 35 | 3.58 | 1.59 | 99% |
| 07 | Day 42 | 3.59 | 1.60 | 100% |
| 08 | Day 49 | 3.60 | 1.60 | 100% |
| 09 | Day 56 | 3.60 | 1.61 | 100% |
| 10 | Day 63 | 3.61 | 1.61 | 100% |
| 11 | Day 70 | 3.61 | 1.61 | 100% |
| 12 | Day 77 | 3.61 | 1.61 | 100% |
Method
Half-life calculation
Retatrutide uses a 6-day comparison half-life. For one injection, remaining amount = dose × 2^(-elapsed time / half-life). The page adds every prior injection at the exact selected interval and assumes the full dose is available at injection time.1
How the summaries are calculated
The cards use a repeating steady-state interval. Peak is the highest modeled value between injections, trough is the value just before the next injection, and average is the interval average. Δ Delta is peak divided by trough. Reached by shot X is the first injection whose peak reaches 95% of the repeating steady-state peak. The table starts at the first injection and shows finite accumulation through shot 12.
What mg eq. means
In the half-life view, mg eq. is the sum of the dose-equivalent amount remaining from every prior injection. Bioavailability and absorption time are not applied.
Scope and limits
The six-day value comes from a small single-dose study in healthy participants. This view applies that average to every dose and interval. It does not adjust for body weight, body composition, or individual variability.
Retatrutide References
- Coskun T, Urva S, Roell WC, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metabolism. 2022;34:1234-1247.
- Eli Lilly and Company. A Single-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3437943 in Healthy Subjects. ClinicalTrials.gov. 2019. NCT03841630.