GLP-1s
Semaglutide, tirzepatide, and retatrutide are three different receptor strategies — not three doses of the same drug. Each one answers the same question about hunger, fat, and lean mass in a different way.
Three compounds, three receptor strategies. Semaglutide activates GLP-1 alone — SELECT showed a 20% cardiovascular event reduction in obesity with established heart disease. Tirzepatide adds GIP and delivered 47% more weight loss than semaglutide in the head-to-head SURMOUNT-5 trial. Retatrutide adds glucagon on top, pushing the weight-loss ceiling higher and mobilizing liver fat directly, though it remains investigational. Pick by the outcome you need, not the headline number.
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Compound Guides
SemaglutideOzempicWegovy
Semaglutide dosing ranges from 0.25mg to 2.4mg a week. How much weight loss to expect by dose, side effects during titration, and if Ozempic or Wegovy is right for you.
Read guideTirzepatideMounjaroZepbound
Tirzepatide dosing ranges from 2.5mg to 15mg. Explore trial data for weight loss, side effects vs. semaglutide, and if Mounjaro or Zepbound makes sense for you.
Read guideDeep Dives
Retatrutide vs TirzepatideSame Receptors, Different Drug
Retatrutide and tirzepatide are not stronger/weaker versions of the same drug. Tirz is the steadier default; reta adds glucagon, liver-fat leverage, and much higher titration risk.
GLP-1 FatigueWhy It Happens and What Helps
GLP-1 fatigue explained: why semaglutide, tirzepatide, and retatrutide cause tiredness, which compound causes more, and evidence-based fixes from protein to mitochondrial support.
Read guideGLP-1s and Cholesterol
GLP-1 drugs also improve lipid panels—lowering triglycerides, shifting LDL, and reducing liver fat. Trial data for semaglutide, tirzepatide, and retatrutide.
Read guideOral GLP-1 OptionsWegovy PillOrforglipron
There's now a pill version of semaglutide, and orforglipron is coming. How they compare on weight loss, side effects, and cost — and if its right for you.
Read guideSupport Stacks for GLP-1sPreserving Lean Mass
GLP-1 body composition explained: semaglutide, tirzepatide, and retatrutide lean-mass data, why muscle loss happens, and how to protect strength during weight loss.
Read guideProtocols
NAD+ for RetatrutideCritical Support Layer for GLP-1s
Retatrutide raises fat-oxidation demand. NAD+ supports beta-oxidation, energy stability, and fatigue resilience during a structured retatrutide protocol.
NAD+ and MOTS-c for EnergyThe Two-Compound Mito Stack
The NAD+ and MOTS-c stack supports the cellular adaptation loop that metabolic stress, GLP-1 use, and age can strain. Full protocol with dosing breakdowns and a 12-week timeline.
Read guideRetatrutide: Advanced StackDual-Axis Protocol to Protect Lean Mass
An advanced retatrutide recomp protocol using NAD+, MOTS-c, L-Carnitine, and Tesamorelin to support fat oxidation, training output, and lean-mass preservation.
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