Integrated Protocol Systems Lab
Turn Deep Peptide Knowledge into Executable Weekly Blueprints.
Select a system—body recomposition, chronic injury recovery, or comprehensive anti-aging—and we convert your cascade logic into an actionable plan. Each protocol includes dosing cadence, weekly expectations, milestone tracking, and end-of-phase check-ins so you can execute like a practitioner while iterating with precision.
Protocol Inputs
Choose the system you want to run, then tune training load, sleep, and genetics. Submit to refresh the blueprint with personalized adjustments and weekly checkpoints.
Lose fat while building resilient muscle through systems-level peptide synergy.
Body Recomposition Engine
Coordinates mitochondrial repair, metabolic redirection, anabolic signaling, and connective-tissue regeneration so caloric deficits preferentially target fat while training outputs climb.
Training: moderate · Sleep: average · Stress: moderate · Goal: recomp
Phase 1 · Mitochondrial Reset & Preparation
Duration · 2 weeks · Focus on mitochondrial foundation and circadian cognitive
Core Stack & Dosing Rhythm
SS-31 (Elamipretide)
morning · 5-10 mg · daily or 3x weekly
Higher ATP production
MOTS-C
morning · 10 mg · 2-3x weekly
Shifts metabolism toward fat utilization
NAD+
intra-day · 200 mg · 3-5x weekly during loading
Universal energy amplification
VIP
morning · 50 mcg · 3-5x weekly
Improves sleep quality and hormonal timing
Semax
morning · 500 mcg · 1-2x daily as needed
Sustains focus during deficit
Selank
intra-day · 500 mcg · 1-3x daily
Prevents stress-induced protocol disruptions
BPC-157
evening · 500 mcg · daily during loading, then 3x weekly
Supports connective tissue adaptation
Mechanistic Rationale & Timing Notes
- SS-31 (Elamipretide): Stabilizes cardiolipin to prevent electron leak → Higher ATP production
- MOTS-C: Activates AMPK signaling → Shifts metabolism toward fat utilization
- NAD+: Provides redox cofactors for ATP production → Universal energy amplification
- VIP: Aligns circadian rhythm and modulates neuroinflammation → Improves sleep quality and hormonal timing
- Semax: Raises BDNF and supports cognitive resilience → Sustains focus during deficit
- Selank: Lowers cortisol and balances autonomic tone → Prevents stress-induced protocol disruptions
- BPC-157: Enhances angiogenesis and fibroblast activity → Supports connective tissue adaptation
- SS-31 (Elamipretide): morning dosing to align with AMPK activation.
- MOTS-C: morning dosing to align with AMPK activation.
- VIP: morning dosing to align with AMPK activation.
- Semax: morning dosing to align with AMPK activation.
- BPC-157: evening dosing to pair with nocturnal GH pulse and mTOR window.
- Synergy · SS-31, NAD+, and MOTS-C establish a mitochondrial foundation that allows high training loads and metabolic stress without fatigue.
- Synergy · VIP anchors circadian rhythm, while DSIP, Semax, and Selank orchestrate neurological state to align AMPK day work with nocturnal mTOR repair.
Weekly Guidance
Week 1
Loading the mitochondria and anchoring circadian timing
Key Actions
- Load SS-31 at 10 mg for days 1-3 before tapering to 5 mg maintenance.
- Administer buffered NAD+ daily with slow IM push and follow with electrolytes.
- Dose VIP within 30 minutes of waking to reinforce cortisol awakening response.
Tracking
- Track afternoon energy levels (1-10 scale) to confirm stability by day 5.
- Hydration goal ≥3 L to mitigate NAD+ flushing.
Expected Changes
- Transient fatigue on days 2-3 is normal while mitochondria remodel.
Week 2
Introduce MOTS-C and light aerobic stimulus
Key Actions
- Begin MOTS-C dosing on M/W/F 30-45 minutes before Zone 2 cardio.
- Increase BPC-157 to daily if connective tissue is deconditioned.
- Log sleep latency and deep sleep minutes to confirm DSIP is unnecessary.
Tracking
- Resting heart rate or HRV trend to ensure systemic stress stays stable.
- Morning bodyweight (3x weekly) to capture hydration normalization.
Expected Changes
- Energy output feels more even by day 10.
- GI calmness improves as gut barrier tightens.
End of Week 2 Review
Phase Review
Prompts
- Is mid-day energy ≥2 points better than baseline?
- Has sleep latency improved and deep sleep reached ≥70 minutes?
- Any localized injection site irritation requiring site rotation?
Metrics to Capture
- Energy 1-10 scale
- Sleep tracker data
- Hydration log
Phase 2 · Metabolic Activation & Fat Mobilization
Duration · 4 weeks · Focus on metabolic engine and anabolic support
Core Stack & Dosing Rhythm
Retatrutide
morning · 1-2 mg · weekly or q72h split
Creates caloric deficit
Tesamorelin
evening · 2 mg · nightly (fasted)
Protects lean mass during deficit
Ipamorelin
evening · 500 mcg · nightly alongside tesamorelin
Enhances anabolic signaling
AOD-9604
morning · 500 mcg · daily (fasted)
Mobilizes fatty acids for oxidation
L-Carnitine
pre-training · 500 mg · daily or tied to training days
Ensures fat mobilization converts to fat oxidation
Selank
intra-day · 500 mcg · 1-3x daily
Prevents stress-induced protocol disruptions
KPV
evening · 500 mcg · daily or as-needed
Maintains clean inflammatory environment
Mechanistic Rationale & Timing Notes
- Retatrutide: Triply agonizes GLP-1, GIP, and glucagon receptors → Creates caloric deficit
- Tesamorelin: Stimulates physiological growth hormone pulses → Protects lean mass during deficit
- Ipamorelin: Activates ghrelin receptor to amplify GH release → Enhances anabolic signaling
- AOD-9604: Stimulates lipolysis without elevating IGF-1 → Mobilizes fatty acids for oxidation
- L-Carnitine: Transports fatty acids across mitochondrial membrane → Ensures fat mobilization converts to fat oxidation
- Selank: Lowers cortisol and balances autonomic tone → Prevents stress-induced protocol disruptions
- KPV: Blocks NF-κB driven inflammation → Maintains clean inflammatory environment
- Retatrutide: morning dosing to align with AMPK activation.
- Tesamorelin: evening dosing to pair with nocturnal GH pulse and mTOR window.
- Ipamorelin: evening dosing to pair with nocturnal GH pulse and mTOR window.
- AOD-9604: morning dosing to align with AMPK activation.
- L-Carnitine: pre-training administration for maximum transport efficiency.
- KPV: evening dosing to pair with nocturnal GH pulse and mTOR window.
- Synergy · Retatrutide-driven caloric deficit is redirected toward fat oxidation when lipolysis, transport, and anabolic signaling are present.
Weekly Guidance
Weeks 3-4
Introduce Retatrutide and align GH secretagogues
Key Actions
- Initiate Retatrutide at 0.5-1 mg split twice weekly to assess tolerance.
- Add Tesamorelin + Ipamorelin nightly (2 mg + 500 mcg) 2-3 hours after final meal.
- Keep AOD-9604 + L-Carnitine fasted pre-cardio to supply alternative fuel.
Tracking
- Waist circumference weekly to ensure visceral fat reduction begins.
- Sleep quality to verify GH pulses are supported.
Expected Changes
- Appetite suppression and slower gastric emptying appear within days.
- Strength holds steady despite caloric restriction.
Weeks 5-6
Escalate intensity once tolerance confirmed
Key Actions
- Advance Retatrutide to 1-2 mg weekly or q72h split if nausea minimal.
- Layer fasted interval sessions 1x weekly while preserving weight training performance.
- Evaluate need for Selank mid-afternoon to blunt stress spikes.
Tracking
- Bodyweight (2x weekly) and training log (load, reps).
- GI tolerance journal for Retatrutide escalation decisions.
Expected Changes
- Visible reduction in abdominal softness by week 6.
- Improved pumps in training from better nutrient partitioning.
Week 6 Recomp Check
Phase Review
Prompts
- Is strength within 95% of baseline numbers?
- Is appetite manageable without binge episodes?
- Any signs of excessive fatigue indicating overreaching?
Metrics to Capture
- Training log comparison
- Waist & weight trend
- Stress score
Phase 3 · Integration & Progressive Overload
Duration · 6 weeks · Focus on recovery repair, anabolic support and mitochondrial foundation
Core Stack & Dosing Rhythm
BPC-157
evening · 500 mcg · daily during loading, then 3x weekly
Supports connective tissue adaptation
TB-500
intra-day · 2-3 mg · 1-2x weekly
Accelerates structural remodeling
GHK-Cu
evening · 2 mg · 3x weekly during integration
Enhances tissue resilience
KPV
evening · 500 mcg · daily or as-needed
Maintains clean inflammatory environment
DSIP
evening · 150 mcg · nightly as needed
Enhances recovery during integration phase
MOTS-C
morning · 10 mg · 2-3x weekly
Shifts metabolism toward fat utilization
Selank
intra-day · 500 mcg · 1-3x daily
Prevents stress-induced protocol disruptions
Mechanistic Rationale & Timing Notes
- BPC-157: Enhances angiogenesis and fibroblast activity → Supports connective tissue adaptation
- TB-500: Mobilizes actin to improve cell migration → Accelerates structural remodeling
- GHK-Cu: Upregulates collagen synthesis → Enhances tissue resilience
- KPV: Blocks NF-κB driven inflammation → Maintains clean inflammatory environment
- DSIP: Improves deep sleep architecture → Enhances recovery during integration phase
- MOTS-C: Activates AMPK signaling → Shifts metabolism toward fat utilization
- Selank: Lowers cortisol and balances autonomic tone → Prevents stress-induced protocol disruptions
- BPC-157: evening dosing to pair with nocturnal GH pulse and mTOR window.
- GHK-Cu: evening dosing to pair with nocturnal GH pulse and mTOR window.
- KPV: evening dosing to pair with nocturnal GH pulse and mTOR window.
- DSIP: evening dosing to pair with nocturnal GH pulse and mTOR window.
- MOTS-C: morning dosing to align with AMPK activation.
- Synergy · BPC-157, TB-500, GHK-Cu, and KPV maintain tissue integrity so progressive training leads to supercompensation instead of injury.
Weekly Guidance
Weeks 7-8
Push volume while protecting connective tissue
Key Actions
- Add TB-500 weekly and increase GHK-Cu to 3 mg 3x/week.
- Introduce Zone 5 sprints or explosive lifts once weekly if joints tolerate.
- Optional DSIP if deep sleep dips below 60 minutes.
Tracking
- Range of motion metrics pre/post sessions.
- Morning joint stiffness rating (0-5).
Expected Changes
- Muscle hardness noticeably improves.
- Joint comfort increases as angiogenesis deepens.
Weeks 9-10
Sustain high output and monitor recovery debt
Key Actions
- Continue MOTS-C once weekly to preserve metabolic flexibility.
- Micro-load training with additional set per body part if recovery metrics positive.
- Run contrast showers and mobility work to keep lymph moving.
Tracking
- HRV or morning pulse to detect accumulated fatigue.
- Sleep architecture from wearable data.
Expected Changes
- Body comp shift becomes obvious to others.
- Skin tone and vascularity improve from GHK-Cu.
Weeks 11-12
Prepare for taper and cement habits
Key Actions
- Begin lowering BPC-157 to 3x/week unless injury risk persists.
- Reduce Tesamorelin to 5 nights/week to start receptor resensitization.
- Audit nutrition adherence and refeed cadence.
Tracking
- Grip strength or vertical jump as readiness proxy.
- Weekly photos to confirm symmetry improvements.
Expected Changes
- Lean mass maintained while fat mass continues to drop.
Week 12 Integration Audit
Phase Review
Prompts
- Are connective tissues pain-free under heavier loads?
- Do recovery metrics stay high despite volume?
- Is Selank still required daily or can frequency drop?
Metrics to Capture
- Readiness score
- Joint pain scale
- Training volume chart
Phase 4 · Consolidation & Taper
Duration · 2 weeks · Focus on mitochondrial foundation and recovery repair
Core Stack & Dosing Rhythm
NAD+
intra-day · 200 mg · 3-5x weekly during loading
Universal energy amplification
BPC-157
evening · 500 mcg · daily during loading, then 3x weekly
Supports connective tissue adaptation
Retatrutide
morning · 1-2 mg · weekly or q72h split
Creates caloric deficit
GHK-Cu
evening · 2 mg · 3x weekly during integration
Enhances tissue resilience
Selank
intra-day · 500 mcg · 1-3x daily
Prevents stress-induced protocol disruptions
Mechanistic Rationale & Timing Notes
- NAD+: Provides redox cofactors for ATP production → Universal energy amplification
- BPC-157: Enhances angiogenesis and fibroblast activity → Supports connective tissue adaptation
- Retatrutide: Triply agonizes GLP-1, GIP, and glucagon receptors → Creates caloric deficit
- GHK-Cu: Upregulates collagen synthesis → Enhances tissue resilience
- Selank: Lowers cortisol and balances autonomic tone → Prevents stress-induced protocol disruptions
- BPC-157: evening dosing to pair with nocturnal GH pulse and mTOR window.
- Retatrutide: morning dosing to align with AMPK activation.
- GHK-Cu: evening dosing to pair with nocturnal GH pulse and mTOR window.
- Synergy · During taper, lower dosing of NAD+, BPC-157, and Retatrutide maintains gains while allowing receptor resensitization.
Weekly Guidance
Week 13
Cut frequencies to 50% while tracking regression
Key Actions
- Drop Tesamorelin to 3 nights/week and MOTS-C to 1x/week.
- Maintain Retatrutide at lowest effective dose (often 1 mg/week).
- Shift BPC-157 to 3x/week for maintenance.
Tracking
- Body weight and waist to ensure no rebound.
- Training log for strength retention.
Expected Changes
- Energy remains elevated despite lower dosing.
Week 14
Finalize maintenance cadence
Key Actions
- Set NAD+ to 1-2x/week and Retatrutide as needed based on appetite control.
- Plan next training mesocycle with deload or new performance target.
- Continue Selank only on stressful days.
Tracking
- Sleep quality for any drop-off after reducing DSIP/Tesamorelin.
Expected Changes
- Look and feel is now baseline; only light adjustments required.
Week 14 Maintenance Set-Point
Phase Review
Prompts
- Did body composition hold steady for two weeks?
- Which peptides remain essential for maintenance vs. can be cycled off?
- Are you mentally ready for next goal block?
Metrics to Capture
- DEXA/InBody if available
- Subjective readiness
- Meal compliance %