Which GLP-1 is Right for You?
Compare GLP-1 drugs based on your tolerance and goals.
Semaglutide
Ozempic, Wegovy
The gentle starter
Reduces appetite and slows digestion for steady but indiscriminate weight loss
GLP-1 only: satiety and insulin sensitivity
Tirzepatide
Mounjaro, Zepbound
The fast track
Dual-action appetite control with enhanced fat loss - more powerful but requires attention to muscle protection
GLP-1 + GIP: deeper metabolic rebalancing with improved nutrient partitioning
Retatrutide
Investigational (Phase 2)
The heavy hitter
Triple-action for maximum fat loss - requires meticulous muscle protection and supervised approach
GLP-1 + GIP + Glucagon: whole-system metabolic rewiring with enhanced fat oxidation
How It Works
Triple Agonist: GLP-1 / GIP / Glucagon
Retatrutide adds glucagon to GLP-1 and GIP. Glucagon raises resting energy expenditure and mobilizes fat—exactly what you want for a hard cut—but it can pull on lean tissue if you aren't anabolic enough.
What This Means
GLP-1/GIP handle appetite and glucose; glucagon increases energy expenditure and lipolysis. The clinical lever is aggressive fat loss only when you steer fuel in the morning and backfill anabolism at night.
Complete Protocol Guide
Start
Build
Maintain
Medical Disclaimer
The content in this GLP-1 comparison guide is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before beginning any new protocol, supplement, or medication.
Do not exceed this dosage. Always follow your healthcare provider's guidance.
Glucagon boosts energy expenditure but can catabolize muscle and increase need for carbohydrate intake if training too hard - slow titration essential.
Advantages
- Highest fat loss potential of any available option.
- Impacts metabolism and drives fat oxidation with glucagon.
Watch Out For
- Side effects highly sensitive to dose escalation.
- Elevated heart-rate during initial titration phases.