GLP Drug Comparison
Which GLP-1 is Right for You?
Compare Semaglutide, Tirzepatide, and Retatrutide based on your tolerance and goals.
Click any option for a complete deep dive
Semaglutide
Ozempic, Wegovy
beginner
Intensity
Tolerability
The gentle starter
Reduces appetite and slows digestion for steady fat loss while protecting muscle
Metabolic Scope
GLP-1 only: satiety and insulin sensitivity
Best For
- First-time GLP users
- Moderate fat loss goals
- Good tolerance to side effects
- Maintaining muscle while cutting
Tirzepatide
Mounjaro, Zepbound
intermediate
Intensity
Tolerability
The fast track
Dual-action appetite control with enhanced fat loss - more powerful but requires attention to muscle protection
Metabolic Scope
GLP-1 + GIP: deeper metabolic rebalancing with improved nutrient partitioning
Best For
- Experienced with appetite suppressants
- Want faster results than semaglutide
- Willing to be disciplined with support protocols
- Type 2 diabetes or sleep apnea
Retatrutide
Investigational (Phase 2)
advanced
Intensity
Tolerability
The heavy hitter
Triple-action for maximum fat loss - requires meticulous muscle protection and supervised approach
Metabolic Scope
GLP-1 + GIP + Glucagon: whole-system metabolic rewiring with enhanced fat oxidation
Best For
- Advanced users with GLP experience
- Willing to be extremely disciplined
- Have muscle protection protocols dialed
- Want maximum fat loss results