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clamp(3.5rem,6vw,5.25rem)}.rs-hero h1{max-width:11ch;margin-top:clamp(1.35rem,2vw,1.9rem);font-size:clamp(4.4rem,8.6vw,7.6rem);line-height:.94}.rs-hero-copy{max-width:43rem;margin-top:clamp(1.25rem,2vw,1.75rem);color:var(--rs-body);font-size:clamp(1.08rem,1.5vw,1.28rem);line-height:1.56;text-wrap:pretty}.rs-premise{display:grid;grid-template-columns:1fr 1fr;max-width:76rem;margin:0 auto;border-top:1px solid var(--rs-line);border-bottom:1px solid var(--rs-line)}.rs-premise div{display:grid;gap:.75rem;min-height:clamp(13rem,20vw,16rem);padding:clamp(1.5rem,3vw,2.3rem);align-content:center}.rs-premise div+div{border-left:1px solid var(--rs-line)}.rs-premise span{color:var(--rs-blue);font-family:var(--font-brown-mono-ll);font-feature-settings:"liga" 0,"dlig" 0,"hist" 0,"calt" 0;font-variant-ligatures:none;font-size:.68rem;text-transform:uppercase}.rs-premise 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h2{max-width:15ch;color:var(--rs-surface);font-size:clamp(3.35rem,5.4vw,5.7rem);line-height:.96}.rs-mechanism-head p{max-width:32rem;color:oklch(82% .018 255);align-self:center;text-wrap:pretty}.rs-mechanism-nav{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:.75rem}.rs-mechanism-nav button{display:grid;gap:.35rem;padding:.84rem 0 .62rem;border:0;border-top:2px solid oklch(42% .04 255);background:transparent;color:oklch(78% .02 255);opacity:.72;text-align:left;cursor:pointer;transition:border-color .18s var(--rs-ease),color .18s var(--rs-ease),opacity .18s var(--rs-ease),transform .16s var(--rs-ease)}.rs-mechanism-nav button.is-active{color:var(--rs-surface);opacity:1}.rs-mechanism-nav button:active{transform:scale(.98)}.rs-mechanism-nav span{font-family:var(--font-brown-mono-ll);font-feature-settings:"liga" 0,"dlig" 0,"hist" 0,"calt" 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minmax(18rem,.34fr);gap:clamp(1.5rem,3vw,2.6rem);align-items:stretch;min-width:0}.rs-atlas{display:block;width:100%;height:auto;min-width:0;aspect-ratio:1100/520;border:0;background:transparent}.rs-atlas-back{fill:transparent}.rs-atlas-dose line,.rs-atlas-rule{stroke:oklch(40% .04 255);stroke-width:1}.rs-atlas-dose text{fill:oklch(82% .018 255);font-family:var(--font-ivar-text);font-size:15px}.rs-route-lane{opacity:.62;transition:filter .22s var(--rs-ease),opacity .22s var(--rs-ease)}.rs-route-lane.is-active{opacity:1;filter:saturate(1.08)}.rs-route-label{fill:var(--rs-surface);font-family:var(--font-ivar-text);font-size:25px;font-weight:500}.rs-route-lane-glp1r .rs-route-label{fill:var(--rs-glp)}.rs-route-lane-gipr .rs-route-label{fill:var(--rs-gip)}.rs-route-lane-gcgr .rs-route-label{fill:var(--rs-gcg)}.rs-route-lane-gipr circle{fill:color-mix(in oklch,var(--rs-gip) 84%,var(--rs-surface))}.rs-route-lane-glp1r circle{fill:color-mix(in oklch,var(--rs-glp) 86%,var(--rs-surface))}.rs-route-lane-gcgr circle{fill:color-mix(in oklch,var(--rs-gcg) 82%,var(--rs-surface))}.rs-route-lane circle{stroke:oklch(12% .028 255);stroke-width:1.25;transition:r .26s var(--rs-ease),opacity .22s var(--rs-ease)}.rs-output-route{opacity:.4;transition:opacity .22s var(--rs-ease)}.rs-output-route.is-active{opacity:1}.rs-output-label{fill:var(--rs-surface);font-family:var(--font-ivar-text);font-size:17px;font-weight:500}.rs-output-route-glp1r .rs-output-label{fill:var(--rs-glp)}.rs-output-route-gipr .rs-output-label{fill:var(--rs-gip)}.rs-output-route-gcgr .rs-output-label{fill:var(--rs-gcg)}.rs-output-detail{fill:oklch(80% .018 255)}.rs-atlas-size-key text,.rs-output-detail{font-family:var(--font-ivar-text);font-size:13px}.rs-atlas-size-key text{fill:oklch(74% .018 255)}.rs-atlas-size-key circle{fill:oklch(78% .018 255);opacity:.86;stroke:oklch(18% .036 255);stroke-width:2}.rs-atlas-callout{display:grid;gap:1rem;align-content:center;padding:.5rem 0 .5rem 1.5rem;border:0;border-left:1px solid oklch(38% .04 255);background:transparent;min-width:0;transition:border-color .22s var(--rs-ease)}.rs-atlas-callout span{font-family:var(--font-brown-mono-ll);font-feature-settings:"liga" 0,"dlig" 0,"hist" 0,"calt" 0;font-variant-ligatures:none;font-size:.68rem;line-height:1.2;text-transform:uppercase}.rs-atlas-act-1 .rs-atlas-callout{border-color:color-mix(in oklch,var(--rs-glp) 68%,oklch(38% .04 255))}.rs-atlas-act-1 .rs-atlas-callout span{color:var(--rs-glp)}.rs-atlas-act-2 .rs-atlas-callout{border-color:color-mix(in oklch,var(--rs-gip) 68%,oklch(38% .04 255))}.rs-atlas-act-2 .rs-atlas-callout span{color:var(--rs-gip)}.rs-atlas-act-3 .rs-atlas-callout{border-color:color-mix(in oklch,var(--rs-gcg) 68%,oklch(38% .04 255))}.rs-atlas-act-3 .rs-atlas-callout span{color:var(--rs-gcg)}.rs-atlas-callout 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span{display:inline-flex;align-items:baseline;color:currentColor;font-family:var(--font-ivar-display);font-size:2.7rem;font-weight:400;line-height:.88;letter-spacing:-.012em;font-variant-numeric:tabular-nums}.rs-dose-wheel-item-unit{display:inline-block;margin-left:.18em;color:var(--rs-blue);font-family:var(--font-ivar-display);font-size:.32em;font-style:italic;font-weight:400;letter-spacing:0;line-height:1;opacity:0;transform:translateX(-2px);transition:opacity .24s var(--rs-ease),transform .28s var(--rs-ease);pointer-events:none}.rs-dose-wheel-item.is-current{color:var(--rs-blue);opacity:1}.rs-dose-wheel-item.is-current span{font-size:5.4rem}.rs-dose-wheel-item.is-current .rs-dose-wheel-item-unit{opacity:1;transform:translateX(0)}.rs-wheel-distance-0{transform:translateY(-50%) scale(1)}.rs-wheel-distance-1.is-before{opacity:.62;transform:translateY(calc(-50% - 5.6rem)) scale(.7)}.rs-wheel-distance-1.is-after{opacity:.62;transform:translateY(calc(-50% + 5.6rem)) scale(.7)}.rs-wheel-distance-2.is-before{opacity:.34;transform:translateY(calc(-50% - 10.4rem)) scale(.5)}.rs-wheel-distance-2.is-after{opacity:.34;transform:translateY(calc(-50% + 10.4rem)) scale(.5)}.rs-wheel-distance-3.is-before{opacity:.18;transform:translateY(calc(-50% - 14.6rem)) scale(.36)}.rs-wheel-distance-3.is-after{opacity:.18;transform:translateY(calc(-50% + 14.6rem)) scale(.36)}.rs-dose-wheel-item.is-hidden{pointer-events:none;opacity:0}.rs-dose-wheel-focus{position:relative;top:auto;left:auto;z-index:3;display:grid;gap:clamp(1.15rem,2vw,1.8rem);padding:clamp(.4rem,1vw,.7rem) 0;align-content:center;transform:none}.rs-dose-wheel-band{font-family:var(--font-brown-mono-ll);font-feature-settings:"liga" 0,"dlig" 0,"hist" 0,"calt" 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p:not(.rs-dose-wheel-band){max-width:clamp(22rem,28vw,26rem);color:var(--rs-body);font-size:clamp(1.24rem,1.48vw,1.52rem);line-height:1.46}.rs-dose-wheel-stage{position:relative;display:block;min-width:0;overflow:visible}.rs-dose-wheel-stage:before{display:none}.rs-dose-wheel-visual{display:grid;align-self:stretch;align-items:center;min-width:0;min-height:100%;padding-left:0}.rs-regime-field{position:relative;display:block;min-height:clamp(24rem,35vw,32rem);margin:0;padding:clamp(1.8rem,3vw,2.8rem) clamp(2.1rem,4.4vw,4.6rem);border:1px solid color-mix(in oklch,var(--rs-blue) 12%,var(--rs-line));border-radius:14px;background:oklch(96% .018 245);overflow:hidden}.rs-regime-heading{position:relative;z-index:3;display:grid;grid-template-columns:minmax(8rem,.7fr) minmax(11rem,1fr) minmax(4.5rem,.35fr);gap:clamp(1rem,2vw,2rem);color:var(--rs-muted);font-family:var(--font-ivar-text);font-size:clamp(.98rem,1.15vw,1.12rem);line-height:1}.rs-regime-orbit{position:relative;display:grid;gap:clamp(.3rem,.7vw,.6rem);margin-top:clamp(1.7rem,3vw,2.6rem)}.rs-regime-axis{position:absolute;top:clamp(6.1rem,8vw,7.8rem);left:38%;z-index:1;width:4px;height:clamp(17rem,25vw,24rem);background:var(--rs-blue);content:"";border-radius:999px;transform:rotate(14deg);transform-origin:center}.rs-regime-node{--rs-signal-size:5rem;--regime-color:var(--rs-blue);--regime-ink:var(--rs-blue);position:relative;z-index:2;display:grid;grid-template-columns:minmax(8rem,.7fr) minmax(11rem,1fr) minmax(4.5rem,.35fr);gap:clamp(1rem,2vw,2rem);align-items:center;width:100%;min-height:clamp(5.4rem,6.8vw,6.9rem)}.rs-regime-node:before{display:none}.rs-regime-signal{display:block;width:var(--rs-signal-size);aspect-ratio:1;justify-self:center;border:4px solid var(--rs-surface);border-radius:50%;background:var(--regime-color);box-shadow:none}.rs-regime-node em{font-size:clamp(2.45rem,3.25vw,3.75rem);font-style:normal}.rs-regime-node em,.rs-regime-node strong{color:var(--regime-ink);font-family:var(--font-ivar-display);font-weight:400;line-height:1;white-space:nowrap}.rs-regime-node strong{justify-self:end;font-size:clamp(1.7rem,2.1vw,2.35rem)}.rs-regime-gipr{--regime-color:var(--rs-gip);--regime-ink:var(--rs-gip-ink)}.rs-regime-glp1r{--regime-color:var(--rs-glp);--regime-ink:var(--rs-glp-ink)}.rs-regime-gcgr{--regime-color:var(--rs-gcg);--regime-ink:var(--rs-gcg-ink)}.rs-regime-node p{max-width:19rem;color:var(--rs-body);font-family:var(--font-ivar-text);font-size:clamp(.9rem,1vw,.98rem);line-height:1.26;text-wrap:pretty}.rs-dose-wheel-phenotype{display:grid;grid-template-columns:minmax(0,.52fr) minmax(0,.48fr);gap:clamp(2rem,5vw,4rem);margin-top:clamp(3rem,5vw,5rem);padding-top:2rem;border-top:1px solid 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var(--rs-line)}.rs-showcase-regime{margin:0;color:var(--rs-blue);font-family:var(--font-ivar-display);font-size:clamp(1.2rem,1.55vw,1.55rem);font-style:normal;font-weight:400;line-height:1.18;letter-spacing:-.008em;text-wrap:balance}.rs-showcase-thesis{max-width:64rem;margin:0;color:var(--rs-body);font-family:var(--font-ivar-text);font-size:clamp(1.05rem,1.2vw,1.2rem);line-height:1.5;text-wrap:pretty}.rs-showcase-receptors{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));column-gap:clamp(1.8rem,3vw,3.4rem);min-width:0}.rs-receptor-col{--receptor-color:var(--rs-blue);--receptor-ink:var(--rs-blue);--receptor-wash:var(--rs-blue-tint);position:relative;display:grid;grid-template-rows:auto auto auto;gap:clamp(.85rem,1.2vw,1.05rem);padding:clamp(.2rem,.6vw,.5rem) 0 0;align-content:start;min-width:0}.rs-receptor-col+.rs-receptor-col:before{content:"";position:absolute;left:calc(clamp(.7rem, 1.4vw, 1.4rem) * 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